Identify the job by title and let the recipient know how you heard about it. Summarize your qualifications for the job, specifically your work experience, activities that show your leadership skills, and your educational background. Ask for an interview, stating where you can be reached and when you will be available. If your prospective employer is located in another city and you plan to visit the area, mention the dates for your trip. If you are applying for a specific job, include any information pertinent to the position that is not included in your resume.
You can also include links to online portfolios, if appropriate, or a link to your professional social media account such as LinkedIn or Twitter. You don't want to make this section too cluttered, however, so restrict yourself to the most relevant information. Here's how to set up an email signature, along with more advice on what to include in it and what to leave off.