Anything that you'd use in an informal communication is inappropriate for a business letter. This includes slang, text_speak, emojis, and anything off_color or casual. If you're used to communicating mostly with friends, family, or even co_workers you've worked with for a long time, an appropriate closing for a business letter will probably feel pretty stilted at first. Don't worry about it – your colleague or business associate won't feel that way when he or she reads your correspondence. What seems unnatural to you will feel respectful and polite to the recipient.
A Note About Email Business Letters. It might be tempting to leave out the closing when you're communicating by email, but don't give in to that temptation. Although no_closing emails are perfectly fine for everyday communication with your friends and teammates, they'll seem brusque – or worse, unprofessional – to people you don't know as well. You should also use a business letter closing when you're corresponding with someone professionally about an important issue, whether it's a new project or a job opportunity.