Not only does this mean that you should focus on neutrality in your letter’s appearance (avoiding the use of colorful paper, brash logo designs, and artistic fonts), but it also means that you should employ a very low_key, unnuanced, and professional closing phrase. The best_case scenario is that the hiring manager, colleague, or connection won't even notice the closing.
You can also include links to online portfolios, if appropriate, or a link to your professional social media account such as LinkedIn or Twitter. You don't want to make this section too cluttered, however, so restrict yourself to the most relevant information. Here's how to set up an email signature, along with more advice on what to include in it and what to leave off.