Not only does this mean that you should focus on neutrality in your letter’s appearance (avoiding the use of colorful paper, brash logo designs, and artistic fonts), but it also means that you should employ a very low_key, unnuanced, and professional closing phrase. The best_case scenario is that the hiring manager, colleague, or connection won't even notice the closing.
When writing an application letter, remember that you probably have competition. Your audience is a professional who screens and hires job applicants—someone who may look through dozens or even hundreds of other applications on the day she receives yours. The immediate objective of your application letter and accompanying resume is to attract this person’s attention. Your ultimate goal is to obtain an interview. As you write your application letter, be sure you complete three tasks: catch the reader’s attention favorably, convince the reader that you are a qualified candidate for the job, and request an interview.