The basic structure of a formal letter: The rules might be arbitrary, but taken together they create a formula that produces clarity. When a letter follows all the rules, the reader doesn’t have to struggle to figure out where a piece of information might be, what action they should take next, or who sent it _ everything can be found in its place. Knowing the rules of letter writing is, in that sense, akin to knowing the rules of page layout or web design _ the format of the document should support and clarify the content.
Remember, you're hoping the person who receives your letter has no memory of your closing at all. The last thing you want is a hiring manager going into an HR meeting with your cover letter in hand, asking the team if they want to meet with "Mr. Kindest Personal Regards."