Not only does this mean that you should focus on neutrality in your letter’s appearance (avoiding the use of colorful paper, brash logo designs, and artistic fonts), but it also means that you should employ a very low_key, unnuanced, and professional closing phrase. The best_case scenario is that the hiring manager, colleague, or connection won't even notice the closing.
When you know the recipient’s name, sign it “Sincerely yours” or just “Sincerely”, or in the US “Yours truly” is acceptable. Don’t try anything more cutesy or friendly unless a) you know the recipient quite well and are certain you can be informal without seeming disrespectful, or b) you have a “trademark” letter ending that’s part of your public persona (and the talent and popularity to pull it off). Signature and printed name: Signing your name is a minimal assurance that you stand behind what was written.