When you know the recipient’s name, sign it “Sincerely yours” or just “Sincerely”, or in the US “Yours truly” is acceptable. Don’t try anything more cutesy or friendly unless a) you know the recipient quite well and are certain you can be informal without seeming disrespectful, or b) you have a “trademark” letter ending that’s part of your public persona (and the talent and popularity to pull it off). Signature and printed name: Signing your name is a minimal assurance that you stand behind what was written.
There is a tendency to think that the often arbitrary rules of letter writing don’t really matter, that as long as your recipient can work out what you’re saying, that’s good enough. This shows a great deal of disrespect for your recipient, though, and for your own ideas. It suggests that a) your reader’s time isn’t valuable enough for you to write clearly and efficiently, and b) that you don’t particularly care about the content of your letter.