It is established etiquette by the Joint Chiefs of Staff, United States Department of Defense, the U.S. Army, the U.S. Navy, and the U.S. Air Force that the closing “Respectfully yours” be reserved for the President of the United States (according to U.S. Army standards, this also extends to the first lady and the President_elect).
To save your reader time and to call attention to your strengths as a candidate, state your objective directly at the beginning of the letter. Example: I am seeking a position as a manager in your Data Center. In such a management position, I can use my master’s degree in information systems and my experience as a programmer/analyst to address business challenges in data processing. If you have been referred to a company by one of its employees, a career counselor, a professor, or someone else, mention that before stating your job objective.