Not only does this mean that you should focus on neutrality in your letter’s appearance (avoiding the use of colorful paper, brash logo designs, and artistic fonts), but it also means that you should employ a very low_key, unnuanced, and professional closing phrase. The best_case scenario is that the hiring manager, colleague, or connection won't even notice the closing.
However, before using a general salutation (or leaving off a salutation), try to find out the name of the person you are contacting. If you are applying or inquiring about a job and the hiring manager’s name is not included on the job listing, you might look up the title of the employer or hiring manager on the company website. If there is a contact number, you might also call and ask an administrative assistant for the name of the hiring manager. If you are sending a different type of letter, you can still look up the person’s name on the company website, or speak to an administrative assistant or contact at the company for the name of the person you are trying to reach.