There is a tendency to think that the often arbitrary rules of letter writing don’t really matter, that as long as your recipient can work out what you’re saying, that’s good enough. This shows a great deal of disrespect for your recipient, though, and for your own ideas. It suggests that a) your reader’s time isn’t valuable enough for you to write clearly and efficiently, and b) that you don’t particularly care about the content of your letter.
Quick Tip: Don't use your work email address for job searching. Use your personal email account, or set up a unique account to use just for your job hunt. Many free online email services exist, like Gmail and Yahoo mail, that you can use to set up a new email account exclusively for your job search.