Contact Information: The first section of your letter should include your contact information and the contact information of the person you are writing, too. Also, include the date you are writing at the top of your letter. Letter Salutation: Unless you know the reader well and typically address them by their first name, you should include the person's personal title and full name in the salutation (i.e., "Dear Mr. James Franklin"). If you are unsure of the reader's name, include his or her title (i.e., "Dear Executive of Marketing"). If you are unsure of the reader's gender, simply state their full name and avoid the personal title (i.e., "Dear Jamie Smith"). If you are unsure of the reader's gender, name, and title, simply write, "To Whom It May Concern." Leave one line blank after the salutation.
Not only does this mean that you should focus on neutrality in your letter’s appearance (avoiding the use of colorful paper, brash logo designs, and artistic fonts), but it also means that you should employ a very low_key, unnuanced, and professional closing phrase. The best_case scenario is that the hiring manager, colleague, or connection won't even notice the closing.